A Pilot Randomized Clinical Safety Study of Sonothrombolysis Augmentation With Ultrasound-Activated Perflutren-Lipid Microspheres for Acute Ischemic Stroke
نویسندگان
چکیده
منابع مشابه
A pilot randomized clinical safety study of sonothrombolysis augmentation with ultrasound-activated perflutren-lipid microspheres for acute ischemic stroke.
BACKGROUND AND PURPOSE Ultrasound transiently expands perflutren-lipid microspheres (muS), transmitting energy momentum to surrounding fluids. We report a pilot safety/feasibility study of ultrasound-activated muS with systemic tissue plasminogen activator (tPA). METHODS Stroke subjects treated within 3 hours had abnormal Thrombolysis in Brain Ischemia (TIBI) residual flow grades 0 to 3 befor...
متن کاملPilot Safety Study of a Novel Operator-Independent Ultrasound Device in Patients With Acute Ischemic Stroke
The benefit of tissue-type plasminogen activator (tPA) in acute stroke is linked to the speed and degree of clot lysis and artery recanalization. However, only 20% to 30% of patients have complete recanalization within 2 hours of intravenous tPA therapy, and up to one third of those with any recanalization experience reocclusion. Adjunctive strategies to augment the reperfusion benefit of intra...
متن کاملCLOTBUST-Hands Free: pilot safety study of a novel operator-independent ultrasound device in patients with acute ischemic stroke.
BACKGROUND AND PURPOSE The Combined Lysis of Thrombus in Brain Ischemia With Transcranial Ultrasound and Systemic T-PA-Hands-Free (CLOTBUST-HF) study is a first-in-human, National Institutes of Health-sponsored, multicenter, open-label, pilot safety trial of tissue-type plasminogen activator (tPA) plus a novel operator-independent ultrasound device in patients with ischemic stroke caused by pro...
متن کاملSonothrombolysis for acute ischaemic stroke.
BACKGROUND Sonothrombolysis is a promising but unproven tool for treating acute ischaemic stroke. There is an ongoing debate about the efficacy, safety, technical aspects of ultrasound administration and the possible potentiating effect of microbubbles. OBJECTIVES To assess the effectiveness and safety of sonothrombolysis in patients with acute ischaemic stroke. SEARCH METHODS We searched t...
متن کاملThe Effect of Intravenous Magnesium Sulfate in Improvement of Acute Ischemic Stroke Induced Disability: A Randomized Double Blinded Clinical Trial
Background: Stroke is the third main cause of death and chronic disabilities in adults, which requires finding neuroprotective drugs to reduce its mortality and morbidity. Objectives: To determine the efficacy of magnesium sulfate as an adjunctive neuroprotective agent in patients with stroke. Materials & Methods: This randomized double-blind clinical trial recruited 120 patients with acute ...
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ژورنال
عنوان ژورنال: Stroke
سال: 2008
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.107.505727